NF1: Seizures

Seizures are seen at a slightly increased frequency in individuals with neurofibromatosis type 1 (NF1) (5-7%) as compared to the general population. [Young: 2002] The natural history and types of seizures in NF1, however, are similar to that in the general population [Korf: 1993]. The seizures are usually not the result of an anatomic abnormality, but any NF1 individual with seizure activity should have an MRI of the brain to look for structural abnormalities and tumors, and be evaluated by a neurologist.

Authors & Reviewers

Current Authors and Reviewers:
Author: David A. Stevenson, MD
Reviewers: Karin Dent, MS, CGC
David Viskochil, MD, Ph.D.

Page Bibliography

Korf BR, Carrazana E, Holmes GL.
Patterns of seizures observed in association with neurofibromatosis 1.
Epilepsia. 1993;34(4):616-20. PubMed abstract
Retrospective review of 359 NF1 individuals looking at seizure frequency.

Young H, Hyman S, North K.
Neurofibromatosis 1: clinical review and exceptions to the rules.
J Child Neurol. 2002;17(8):613-621. PubMed abstract
Concise, up to date, review of clinical aspects of NF1 with focus on unusual manifestations.